TIsigner Translation Initiation coding region designer
TIsigner optimises the translation initiation coding region of a gene of interest to improve recombinant protein production in Escherichia coli, Saccharomyces cerevisiae and Mus musculus. In contrast to existing software, TIsigner suggests minimum numbers of synonymous codon changes to the input sequence. This enables a standard PCR cloning for the optimised sequence.
DOI: 10.1371/journal.pcbi.1009461
TIsigner optimises the translation initiation coding region of a gene of interest to improve recombinant protein production in Escherichia coli, Saccharomyces cerevisiae and Mus musculus. In contrast to existing software, TIsigner suggests minimum numbers of synonymous codon changes to the input sequence. This enables a standard PCR cloning for the optimised sequence.
DOI: 10.1371/journal.pcbi.1009461