TIsigner

Unleash the power of synthetic biology





Our open source, industry-leading platform offers unparalleled speed and accuracy for gene optimisation.






SoDoPE logo

SoDoPE enables users to navigate a protein sequence and its domains for predicting and maximising solubility. SoDoPE is linked with TIsigner, and therefore empowers protein biochemists to design sequences for tuning both protein expression and solubility for a gene of interest.

TIsigner logo

TIsigner optimises the translation initiation coding region of a gene of interest to improve recombinant protein production in Escherichia coli, Saccharomyces cerevisiae and Mus musculus. In contrast to existing software, TIsigner suggests minimum numbers of synonymous codon changes to the input sequence. This enables a standard PCR cloning for the optimised sequence.

Leveraging 98,146 real-world experimental data points, our algorithms withstand the world's most stringent tests.